Sacrifice of Isaac is a oil on canvas painting by Michelangelo Merisi da Caravaggio (1571–1610), created in c. 1598. Measuring 173 × 116 cm, it depicts the biblical scene from Genesis 22:1-19.
The Sacrifice of Isaac is the title of two paintings from c. 1598 - 1603 depicting the sacrifice of Isaac. The paintings could be painted by the Italian master Caravaggio (1571–1610) but there is also strong evidence that they may have been the work of Bartolomeo Cavarozzi, a talented early member of the Caravaggio following who is known to have been in Spain about 1617–1619.