On 27 October 1480, several Florentine painters left for Rome, where they had been called as part of the reconciliation project between Lorenzo de' Medici, the de facto ruler of Florence, and Pope Sixtus IV. The Florentines started to work in the Sistine Chapel as early as spring 1481, along with Pietro Perugino, who was already there. Rosselli brought with him his son-in-law, Piero di Cosimo, who perhaps collaborated on this painting and at least one of the others assigned by his master.
The theme of the decoration was a parallel between the stories of Moses and those of Christ, as a sign of continuity between the Old Testament and the New Testament, as well as a continuity between the divine law of the Tables and the message of Jesus, who, in turn, chose Peter (the first alleged bishop of Rome) as his successor: this would finally result in a legitimation of the latter's successors, the popes of Rome.